【研究】新型コロナウイルス治療に有効な食物成分をインドの研究者が発見。一番効果があるのは…

査読の段階ではありますが、インドの研究者がコロナ治療に有効な食物成分を発見しています。１番目の成分はレムデシビルより抗ウィルス作用が高いと。含まれる食品は「緑茶」。

1. エピガロカテキンガレート
2. クルクミン
3. アピゲニン
4. ベータグルカン
5. ミリセチン
https://www.researchsquare.com/article/rs-19560/v1

タイトル「分子ドッキング研究を使用してCOVID-19と戦うための治療薬としての食物分子の同定」

これは、インドのERA医科大学という医大の研究者たちが、18種類の食品の成分について「分子ドッキング」という方法で研究した論文です。

Identification of Dietary Molecules as Therapeutic Agents to Combat COVID-19 Using Molecular Docking Studies
Mohammad Faheem Khan, Mohsin Ali Khan, Zaw Ali Khan, Tanv

Recently, a new and fatal strain of coronavirus named as SARS-CoV-2 (Disease: COVID-19) appeared in Wuhan, China in December of 2019. Due to its fast growing human to human transmission and confirmed cases in nearly every country, it has been declared as pandemic by World Health Organisation (WHO) on 11 March 2020. Till now, there is no therapy such as vaccines and specific therapeutic agents available globally. Inspite of this, some protease inhibitors and antiviral agents namely lopinavir, ritonavir, remdisivir and chloroquine are under investigation and also implemented in several countries as therapeutic agents for the treatment of COVID-19. Seeing the health crisis across the world, it was our aim to find out a suitable drug candidate which could target SARS-CoV-2. For this purpose, molecular docking of 7 proteinsof SARS-CoV-2 was done with 18active constituents that have previously been reported to be antiviral or anti-SARS-CoV agents. The docking results of these 18 compounds were compared with 2 FDA approved drugs that have are currently being used in COVID 19, namely Remdesivir and Chloroquine. Our result revealed that among all, epigallocatechin gallate (EGCG), a major constituent of green tea, is the lead compound that could fit well into the binding sites of docked proteins of SARS-CoV-2. EGCG showed very strong molecular interactions with binding energies -9.30, -8.66, -8.38, -7.57, -7.26, -6.99 and -4.90 kcal/mole for6y2e, 6vw1, 6vww, 6lxt,6vsb, 6lu7 and 6lvnproteins of SARS-CoV-2, respectively.Therefore, EGCG as per our results, should be explored as a drug candidate for the treatment of COVID-19.

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